Kinetic evidence for both a fast and a slow secretory pathway for apolipoprotein A-I in humans

• Published in: Journal of lipid research Vol. 36; no. 7; pp. 1618 - 1628
• Main Authors: Fisher, W R, Venkatakrishnan, V, Zech, L A, Hall, C M, Kilgore, L L, Stacpoole, P W, Diffenderfer, M R, Friday, K E, Sumner, A E, Marsh, J B
• Format: Journal Article
• Language: English
• Published: United States Elsevier 01.07.1995
• Subjects: Apolipoprotein A-I - biosynthesis; Apolipoprotein A-I - metabolism; Apolipoprotein A-II - biosynthesis; Apolipoprotein A-II - metabolism; Female; Humans; Hyperlipoproteinemia Type II - blood; Kinetics; Leucine - metabolism; Middle Aged; Tritium

The kinetics of apolipoproteins A-I and A-II were examined in human subjects using leucine tracers administered intravenously. High density lipoproteins were separated and apoA-I and A-II were isolated. The specific activity or enrichment data for these apolipoprotein were analyzed by mathematical c...