Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization
AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one mo...
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| Published in | World journal of gastroenterology : WJG Vol. 22; no. 47; pp. 10406 - 10414 |
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| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Baishideng Publishing Group Inc
21.12.2016
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| Abstract | AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. |
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| AbstractList | To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.
We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients were seen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control (LLC), distant liver control (DLC), time to distant metastases (DM), progression free survival (PFS) and overall survival (OS).
The majority of patients were males (
= 25, 74%), and had Child Pugh Class A (
= 31, 91%), with a median age of 68 years (46-84 years). FDG-avid disease was found in 19 (56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC (
= 0.02). Median follow up of patients following radioembolization was 12 months (1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS (
< 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS (all
< 0.05).
In this retrospective study, pre-treatment HCC FDG-avidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. |
| Author | Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer Sweeney Daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad |
| AuthorAffiliation | Department of Radiation Oncology, H Lee Moffitt Cancer Center and Research Institute;Department of Interventional Radiology, H Lee Moffitt Cancer Center and Research Institute;Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute |
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| Keywords | Hepatocellular carcinoma Biomarker F-18 fluorodeoxyglucose PET Prognosis Radioembolization |
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| Notes | Yazan Abuodeh;Arash O Naghavi;Kamran A Ahmed;Puja S Venkat;Youngchul Kim;Bela Kis;Junsung Choi;Benjamin Biebel;Jennifer Sweeney;Daniel A Anaya;Richard Kim;Mokenge Malafa;Jessica M Frakes;Sarah E Hoffe;Ghassan El-Haddad;Department of Radiation Oncology, H Lee Moffitt Cancer Center and Research Institute;Department of Interventional Radiology, H Lee Moffitt Cancer Center and Research Institute;Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute Correspondence to: Ghassan El-Haddad, MD, Department of Interventional Radiology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, United States. ghassan.elhaddad@moffitt.org Author contributions: Abuodeh Y, Naghavi AO, Ahmed KA, Venkat PS, Kim Y, Hoffe SE and El-Haddad G participated in conception and design, acquisition of data, or analysis and interpretation of data; Abuodeh Y, Naghavi AO, Ahmed KA, Venkat PS, Kis B, Choi J, Biebel B, Sweeney J, Anaya DA, Kim R, Malafa M, Frakes JM, Hoffe SE and El-Haddad G were involved in drafting or revising of the manuscript critically for important intellectual content; Abuodeh Y, Naghavi AO, Ahmed KA, Venkat PS, Kim Y, Kis B, Choi J, Biebel B, Sweeney J, Anaya DA, Kim R, Malafa M, Frakes JM, Hoffe SE and El-Haddad G approved final manuscript for submission and publication. Telephone: +1-813-7458425 Fax: +1-813-7451535 |
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| Snippet | AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who... To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization. We identified 34 patients with HCC who underwent... |
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| SubjectTerms | Aged Aged, 80 and over Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - radiotherapy Carcinoma, Hepatocellular - secondary Chi-Square Distribution Disease Progression Disease-Free Survival Embolization, Therapeutic - adverse effects Embolization, Therapeutic - methods Female Florida Fluorodeoxyglucose F18 - administration & dosage Humans Kaplan-Meier Estimate Liver Neoplasms - diagnostic imaging Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - radiotherapy Male Microspheres Middle Aged Multivariate Analysis Neoplasm Recurrence, Local Positron Emission Tomography Computed Tomography Predictive Value of Tests Proportional Hazards Models Radiopharmaceuticals - administration & dosage Radiopharmaceuticals - adverse effects Retrospective Studies Retrospective Study Risk Factors Time Factors Treatment Outcome Yttrium Radioisotopes - administration & dosage Yttrium Radioisotopes - adverse effects |
| Title | Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization |
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