Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal cancers to radiotherapy

• Published in: World journal of gastroenterology : WJG Vol. 20; no. 43; pp. 16268 - 16274
• Main Authors: Wu, Xiao-Yu, Wu, Zhen-Feng, Cao, Qin-Hong, Chen, Che, Chen, Zhi-Wei, Xu, Zhe, Li, Wei-Su, Liu, Fu-Kun, Yao, Xue-Quan, Li, Gang
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 21.11.2014
• Subjects: Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Biopsy; carci; Carcinoma - chemistry; Carcinoma - pathology; Carcinoma - radiotherapy; Carcinoma - surgery; factor-1; Female; Fibrosis; growth; Humans; Immunohistochemistry; Insulin-like; Male; Middle Aged; Necrosis; Neoadjuvant Therapy; Neoplasm Staging; Radiation Tolerance; Radiotherapy, Adjuvant; Radiotherapy, Intensity-Modulated; receptor; Receptors, Somatomedin - genetics; Receptors, Somatomedin - metabolism; Rectal; Rectal Neoplasms - genetics; Rectal Neoplasms - metabolism; Rectal Neoplasms - pathology; Rectal Neoplasms - radiotherapy; Rectal Neoplasms - surgery; Retrospective Studies; Retrospective Study; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Time Factors; Treatment Outcome; Up-Regulation; Immunohistochemistry; Preoperative radiotherapy; Insulin-like growth factor-1 receptor; Reverse transcription-polymerase chain reaction; Rectal carcinoma
• ISSN: 1007-9327; 2219-2840; 2219-2840
• DOI: 10.3748/wjg.v20.i43.16268

AIM:To explore the potential correlation between insulin-like growth factor receptor-1(IGF-1R)expression and rectal cancer radiosensitivity.METHODS:Eighty-seven rectal cancer patients(c TNMⅠ-Ⅲ)treated in our department between January 2011and December 2012 were enrolled.All subjects were treated wit...