Comparative parallel analysis of RNA ends identifies mRNA substrates of a tRNA splicing endonuclease-initiated mRNA decay pathway

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 118; no. 10; pp. 1 - 12
• Main Authors: Hurtig, Jennifer E., Steiger, Michelle A., Nagarajan, Vinay K., Li, Tao, Chao, Ti-Chun, Tsai, Kuang-Lei, van Hoof, Ambro
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 09.03.2021
• Subjects: Amino acids; Biological Sciences; Cleavage; Decay; Endonuclease; Eukaryotes; Hypoplasia; Introns; Localization; Mitochondria; mRNA turnover; Mutation; Splicing; Substrates; Target recognition; Transfer RNA; tRNA; Yeast; Yeasts; endonuclease; mRNA degradation; tRNA splicing

Eukaryotes share a conserved messenger RNA (mRNA) decay pathway in which bulk mRNA is degraded by exoribonucleases. In addition, it has become clear that more specialized mRNA decay pathways are initiated by endonucleolytic cleavage at particular sites. The transfer RNA (tRNA) splicing endonuclease...