CX3CR1(+) B Cells Show Immune Suppressor Properties

• Published in: The Journal of biological chemistry Vol. 289; no. 33; pp. 22630 - 22635
• Main Author: Wu, Zhiqiang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.08.2014; American Society for Biochemistry and Molecular Biology
• Subjects: Adult; Antigens, Neoplasm - biosynthesis; Antigens, Neoplasm - immunology; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; B-Lymphocyte Subsets - pathology; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - pathology; Cell Proliferation; CX3C Chemokine Receptor 1; Female; Food Hypersensitivity - blood; Food Hypersensitivity - immunology; Food Hypersensitivity - pathology; Gene Expression Regulation - immunology; Humans; Immune Tolerance; Immunology; Integrins - biosynthesis; Integrins - immunology; Lymphocyte Activation; Male; Middle Aged; Receptors, Chemokine - immunology; Receptors, Chemokine - metabolism; Allergy; Flow Cytometry; Western Blot; Lymphocyte; Cytokine

The immune regulatory functions of B cells are not fully understood yet. The present study aims to characterize a subtype of B cells that expresses CX3CR1. In this study, peripheral blood samples were collected from patients with food allergies and healthy subjects. Peripheral B cells were analyzed...