Circulating microRNAs as Reliable Tumor Biomarkers: Opportunities and Challenges Facing Clinical Application

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 384; no. 1; pp. 35 - 51
• Main Authors: El-Daly, Sherien M., Gouhar, Shaimaa A., Abd Elmageed, Zakaria Y.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2023; The American Society for Pharmacology and Experimental Therapeutics
• Subjects: Biomarkers, Tumor - blood; Circulating MicroRNA - blood; Humans; Neoplasms - blood; Neoplasms - diagnosis; Prognosis; Special Section on Non-Coding RNAs in Clinical Practice: From Biomarkers to Therapeutic Tools—Minireview; AST; AFP-L3; ALT; HCC; AFP; AUC; DCP; OC; CRC; CA15.3; miRNA; GC; RT-qPCR; CEA; BA

MicroRNAs (miRNAs) are involved in the development of human malignancies, and cells have the ability to secrete these molecules into extracellular compartments. Thus, cell-free miRNAs (circulating miRNAs) can potentially be used as biomarkers to evaluate pathophysiological changes. Although circulat...