Characterization of 29 newly isolated bacteriophages as a potential therapeutic agent against IMP-6-producing Klebsiella pneumoniae from clinical specimens

• Published in: Microbiology spectrum Vol. 11; no. 5; p. e0476122
• Main Authors: Kondo, Kohei, Nakano, Satoshi, Hisatsune, Junzo, Sugawara, Yo, Kataoka, Michiyo, Kayama, Shizuo, Sugai, Motoyuki, Kawano, Mitsuoki
• Format: Journal Article
• Language: English
• Published: 1752 N St., N.W., Washington, DC American Society for Microbiology 01.10.2023
• Subjects: bacteriophages; bla IMP-6; Klebsiella pneumoniae; phage library; phage-resistant bacteria; trade-off

Carbapenemase-producing Enterobacteriaceae (CPE) are one of the most detrimental species of antibiotic-resistant bacteria globally. Phage therapy has emerged as an effective strategy for the treatment of CPE infections. In western Japan, the rise of Klebsiella pneumoniae strains harboring the pKPI-6...