Extracellular Vesicles as Mediators and Potential Targets in Combating Cancer Drug Resistance

• Published in: Molecules (Basel, Switzerland) Vol. 30; no. 3; p. 498
• Main Authors: Zhang, Haodong, Wu, Bohan, Wang, Yanheng, Du, Huamao, Fang, Liaoqiong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.01.2025; MDPI
• Subjects: Analysis; Androgens; Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis; Autophagy - drug effects; Biosynthesis; Breast cancer; Cancer; cancer drug resistance; Cancer therapies; Drug Delivery Systems; Drug dosages; Drug resistance; Drug Resistance, Neoplasm - drug effects; Drug therapy; Drugs; Enzymes; EVs biogenesis; Extracellular vesicles; Extracellular Vesicles - drug effects; Extracellular Vesicles - metabolism; Health aspects; Humans; Leukemia; Lung cancer; molecular mechanisms; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; Oncology, Experimental; Ovarian cancer; Prostate cancer; Review; Signal transduction; therapeutic interventions; tumor microenvironment; Tumor Microenvironment - drug effects; Vehicles; therapeutic interventions; cancer drug resistance; molecular mechanisms; extracellular vesicles; tumor microenvironment; EVs biogenesis

Extracellular vesicles (EVs) are key mediators in the communication between cancer cells and their microenvironment, significantly influencing drug resistance. This review provides a comprehensive analysis of the roles of EVs in promoting drug resistance through mechanisms such as drug efflux, apopt...