Extracellular Vesicles as Mediators and Potential Targets in Combating Cancer Drug Resistance

Extracellular vesicles (EVs) are key mediators in the communication between cancer cells and their microenvironment, significantly influencing drug resistance. This review provides a comprehensive analysis of the roles of EVs in promoting drug resistance through mechanisms such as drug efflux, apopt...

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Published inMolecules (Basel, Switzerland) Vol. 30; no. 3; p. 498
Main Authors Zhang, Haodong, Wu, Bohan, Wang, Yanheng, Du, Huamao, Fang, Liaoqiong
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.01.2025
MDPI
Subjects
Analysis
Androgens
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis
Autophagy - drug effects
Biosynthesis
Breast cancer
Cancer
cancer drug resistance
Cancer therapies
Drug Delivery Systems
Drug dosages
Drug resistance
Drug Resistance, Neoplasm - drug effects
Drug therapy
Drugs
Enzymes
EVs biogenesis
Extracellular vesicles
Extracellular Vesicles - drug effects
Extracellular Vesicles - metabolism
Health aspects
Humans
Leukemia
Lung cancer
molecular mechanisms
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Oncology, Experimental
Ovarian cancer
Prostate cancer
Review
Signal transduction
therapeutic interventions
tumor microenvironment
Tumor Microenvironment - drug effects
Vehicles
therapeutic interventions
cancer drug resistance
molecular mechanisms
extracellular vesicles
tumor microenvironment
EVs biogenesis
Online AccessGet full text
ISSN1420-3049
1420-3049
DOI10.3390/molecules30030498

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Abstract Extracellular vesicles (EVs) are key mediators in the communication between cancer cells and their microenvironment, significantly influencing drug resistance. This review provides a comprehensive analysis of the roles of EVs in promoting drug resistance through mechanisms such as drug efflux, apoptosis resistance, autophagy imbalance, and tumor microenvironment modulation. Despite extensive research, details of EVs biogenesis, cargo selection, and specific pathways in EVs-mediated drug resistance are not fully understood. This review critically examines recent advancements, highlighting key studies that elucidate the molecular mechanisms of EVs functions. Additionally, innovative therapeutic strategies targeting EVs are explored, including inhibiting EVs biogenesis, engineering EVs for drug delivery, and identifying resistance-inhibiting molecules within EVs. By integrating insights from primary research and proposing new directions for future studies, this review aims to advance the understanding of EVs in cancer biology and foster effective interventions to mitigate drug resistance in cancer therapy.
AbstractList Extracellular vesicles (EVs) are key mediators in the communication between cancer cells and their microenvironment, significantly influencing drug resistance. This review provides a comprehensive analysis of the roles of EVs in promoting drug resistance through mechanisms such as drug efflux, apoptosis resistance, autophagy imbalance, and tumor microenvironment modulation. Despite extensive research, details of EVs biogenesis, cargo selection, and specific pathways in EVs-mediated drug resistance are not fully understood. This review critically examines recent advancements, highlighting key studies that elucidate the molecular mechanisms of EVs functions. Additionally, innovative therapeutic strategies targeting EVs are explored, including inhibiting EVs biogenesis, engineering EVs for drug delivery, and identifying resistance-inhibiting molecules within EVs. By integrating insights from primary research and proposing new directions for future studies, this review aims to advance the understanding of EVs in cancer biology and foster effective interventions to mitigate drug resistance in cancer therapy.Extracellular vesicles (EVs) are key mediators in the communication between cancer cells and their microenvironment, significantly influencing drug resistance. This review provides a comprehensive analysis of the roles of EVs in promoting drug resistance through mechanisms such as drug efflux, apoptosis resistance, autophagy imbalance, and tumor microenvironment modulation. Despite extensive research, details of EVs biogenesis, cargo selection, and specific pathways in EVs-mediated drug resistance are not fully understood. This review critically examines recent advancements, highlighting key studies that elucidate the molecular mechanisms of EVs functions. Additionally, innovative therapeutic strategies targeting EVs are explored, including inhibiting EVs biogenesis, engineering EVs for drug delivery, and identifying resistance-inhibiting molecules within EVs. By integrating insights from primary research and proposing new directions for future studies, this review aims to advance the understanding of EVs in cancer biology and foster effective interventions to mitigate drug resistance in cancer therapy.
Extracellular vesicles (EVs) are key mediators in the communication between cancer cells and their microenvironment, significantly influencing drug resistance. This review provides a comprehensive analysis of the roles of EVs in promoting drug resistance through mechanisms such as drug efflux, apoptosis resistance, autophagy imbalance, and tumor microenvironment modulation. Despite extensive research, details of EVs biogenesis, cargo selection, and specific pathways in EVs-mediated drug resistance are not fully understood. This review critically examines recent advancements, highlighting key studies that elucidate the molecular mechanisms of EVs functions. Additionally, innovative therapeutic strategies targeting EVs are explored, including inhibiting EVs biogenesis, engineering EVs for drug delivery, and identifying resistance-inhibiting molecules within EVs. By integrating insights from primary research and proposing new directions for future studies, this review aims to advance the understanding of EVs in cancer biology and foster effective interventions to mitigate drug resistance in cancer therapy.
Audience Academic
Author Wu, Bohan
Du, Huamao
Zhang, Haodong
Wang, Yanheng
Fang, Liaoqiong
AuthorAffiliation 1 College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China; zhanghaodong1258@outlook.com (H.Z.); duhmao@swu.edu.cn (H.D.)
2 Westa College, Southwest University, Chongqing 400715, China; jane721015@outlook.com (B.W.); wyh7786@outlook.com (Y.W.)
3 National Engineering Research Center of Ultrasound Medicine, Chongqing 401121, China
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cancer drug resistance
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tumor microenvironment
EVs biogenesis
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Snippet Extracellular vesicles (EVs) are key mediators in the communication between cancer cells and their microenvironment, significantly influencing drug resistance....
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SubjectTerms Analysis
Androgens
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis
Autophagy - drug effects
Biosynthesis
Breast cancer
Cancer
cancer drug resistance
Cancer therapies
Drug Delivery Systems
Drug dosages
Drug resistance
Drug Resistance, Neoplasm - drug effects
Drug therapy
Drugs
Enzymes
EVs biogenesis
Extracellular vesicles
Extracellular Vesicles - drug effects
Extracellular Vesicles - metabolism
Health aspects
Humans
Leukemia
Lung cancer
molecular mechanisms
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Oncology, Experimental
Ovarian cancer
Prostate cancer
Review
Signal transduction
therapeutic interventions
tumor microenvironment
Tumor Microenvironment - drug effects
Vehicles
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Title Extracellular Vesicles as Mediators and Potential Targets in Combating Cancer Drug Resistance
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Volume 30
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