Synthetic addiction extends the productive life time of engineered Escherichia coli populations - Rugbjerg, Peter; Sarup-Lytzen, Kira; Nagy, Mariann; Sommer, Morten Otto Alexander (Proceedings of the National Academy of Sciences - PNAS, 2018)
Keywords: Acid production; Addictions; Bioengineering; Biological evolution; Biological Sciences; Bioreactors - microbiology; Biosensors; Biosynthesis; Cellular manufacture; Cultivation; Deoxyribonucleic acid; DNA; DNA sequencing; E coli; Escherichia coli - genetics; Escherichia coli - metabolism; Escherichia coli - physiology; Evolution, Molecular; Fermentation; Gene expression; Genes; Genes, Bacterial - genetics; Genes, Essential - genetics; Genetic diversity; Genetic variance; Genetics; Heterogeneity; Metabolic Engineering - methods; Metabolites; Mevalonic acid; Mevalonic Acid - analysis; Mevalonic Acid - metabolism; Population genetics; Populations; Redesign; Sustainability; Sustainability transitions; Sustainable production; Synthetic Biology - methods; scale-up; synthetic biology; population dynamics; genetic heterogeneity