Double-negative T cells remarkably promote neuroinflammation after ischemic stroke

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 12; pp. 5558 - 5563
• Main Authors: Meng, Hailan, Zhao, Haoran, Cao, Xiang, Hao, Junwei, Zhang, He, Liu, Yi, Zhu, Min-sheng, Fan, Lizhen, Weng, Leihua, Qian, Lai, Wang, Xiaoying, Xu, Yun
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 19.03.2019
• Subjects: Aged, 80 and over; Animals; Biological Sciences; Brain; Brain - immunology; Brain injury; Brain Ischemia - immunology; CD3 antigen; CD3 Complex - immunology; CD4 antigen; CD4 Antigens - immunology; CD8 antigen; CD8 Antigens - immunology; Central nervous system; Disease Models, Animal; FasL protein; Female; Head injuries; Homeostasis; Humans; Immunology; Inflammation; Inflammation - immunology; Ischemia; Lymphocytes; Lymphocytes T; Male; Mice; Mice, Inbred C57BL; Microglia - immunology; Peripheral blood; PTPN2 protein; Signal transduction; Stroke; Stroke - immunology; T-Lymphocyte Subsets - immunology; Time dependence; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-α; DNTs; FasL; neuroinflammation; T cell-mediated immunity; ischemic stroke

CD3⁺CD4⁻CD8⁻ T cells (double-negative T cells; DNTs) have diverse functions in peripheral immune-related diseases by regulating immunological and inflammatory homeostasis. However, the functions of DNTs in the central nervous system remain unknown. Here, we found that the levels of DNTs were dramati...