Krüppel-like Factor 11 Differentially Couples to Histone Acetyltransferase and Histone Methyltransferase Chromatin Remodeling Pathways to Transcriptionally Regulate Dopamine D2 Receptor in Neuronal Cells

• Published in: The Journal of biological chemistry Vol. 287; no. 16; pp. 12723 - 12735
• Main Authors: Seo, Seungmae, Lomberk, Gwen, Mathison, Angela, Buttar, Navtej, Podratz, Jewel, Calvo, Ezequiel, Iovanna, Juan, Brimijoin, Stephen, Windebank, Anthony, Urrutia, Raul
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.04.2012; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Apoptosis Regulatory Proteins; Base Sequence; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Differentiation - physiology; Chromatin - metabolism; Dopamine Receptors; Dopaminergic Neurons - cytology; Dopaminergic Neurons - enzymology; Down-Regulation - physiology; Heterochromatin Protein 1 (HP1); Histone Acetyltransferases - metabolism; Histone Methyltransferases; Histone-Lysine N-Methyltransferase - metabolism; Homeostasis - physiology; Humans; Krüppel-like Factor (KLF); Molecular Sequence Data; Neurites - physiology; Neurobiology; Neurotransmitter Receptors; p300; PC12 Cells; Promoter Regions, Genetic - physiology; Rats; Receptors, Dopamine D2 - genetics; Repressor Proteins - genetics; Repressor Proteins - metabolism; Transcription Regulation; Transcription, Genetic - physiology; p300; Neurotransmitter Receptors; Heterochromatin Protein 1 (HP1); Transcription Regulation; Krüppel-like Factor (KLF); Dopamine Receptors

The importance of Krüppel-like factor (KLF)-mediated transcriptional pathways in the biochemistry of neuronal differentiation has been recognized relatively recently. Elegant studies have revealed that KLF proteins are important regulators of two major molecular and cellular processes critical for n...