The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 2; pp. 1090 - 1096
• Main Authors: Bastida, Maria Félix, Pérez-Gómez, Rocío, Trofka, Anna, Zhu, Jianjian, Rada-Iglesias, Alvaro, Sheth, Rushikesh, Stadler, H. Scott, Mackem, Susan, Ros, Marian A.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 14.01.2020
• Subjects: Adaptation; Animals; Biological Sciences; Body Patterning; Extremities - growth & development; Gene expression; Gene Expression Regulation, Developmental; Gene regulation; Gli3 protein; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Limbs; Mice; Mice, Inbred C57BL; Mice, Knockout; Modulation; Morphology; Mutants; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Regulatory sequences; Territory; Transcription; Transcription Factors - genetics; Transcription Factors - metabolism; Transcriptome; Zinc Finger Protein Gli3 - genetics; Zinc Finger Protein Gli3 - metabolism; limb development; Hox genes; thumb; Gli3

In the tetrapod limb, the digits (fingers or toes) are the elements most subject to morphological diversification in response to functional adaptations. However, despite their functional importance, the mechanisms controlling digit morphology remain poorly understood. Here we have focused on underst...