Molecular Circuitry of the SUMO (Small Ubiquitin-like Modifier) Pathway in Controlling Sumoylation Homeostasis and Suppressing Genome Rearrangements

• Published in: The Journal of biological chemistry Vol. 291; no. 16; pp. 8825 - 8835
• Main Authors: de Albuquerque, Claudio Ponte, Liang, Jason, Gaut, Nathaniel James, Zhou, Huilin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2016; American Society for Biochemistry and Molecular Biology
• Subjects: Acetyltransferases - genetics; Acetyltransferases - metabolism; Cell Nucleolus - genetics; Cell Nucleolus - metabolism; Cysteine Endopeptidases - genetics; Cysteine Endopeptidases - metabolism; cysteine protease; DNA and Chromosomes; DNA helicase; DNA recombination; DNA replication; DNA Replication - physiology; DNA, Fungal - biosynthesis; DNA, Fungal - genetics; Endopeptidases - genetics; Endopeptidases - metabolism; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; small ubiquitin-like modifier (SUMO); SUMO-1 Protein - genetics; SUMO-1 Protein - metabolism; Sumoylation - physiology; cysteine protease; DNA helicase; DNA replication; small ubiquitin-like modifier (SUMO); DNA recombination

Small ubiquitin-like modifier (SUMO) E3 ligases are known to have a major role in preventing gross chromosomal rearrangements (GCRs); however, relatively little is known about the role of SUMO isopeptidases in genome maintenance and their role in controlling intracellular sumoylation homeostasis. He...