Vimentin-positive circulating tumor cells as a biomarker for diagnosis and treatment monitoring in patients with pancreatic cancer

• Published in: Cancer letters Vol. 452; pp. 237 - 243
• Main Authors: Wei, Tao, Zhang, Xiaoyu, Zhang, Qi, Yang, Jiaqi, Chen, Qi, Wang, Jianxin, Li, Xiang, Chen, Junye, Ma, Tao, Li, Guogang, Gao, Shunliang, Lou, Jianying, Que, Risheng, Wang, Yi, Dang, Xiaowei, Zheng, Lei, Liang, Tingbo, Bai, Xueli
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.06.2019; Elsevier Limited
• Subjects: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antigens; Antigens, Tumor-Associated, Carbohydrate - analysis; Biomarker; Biomarkers; Biomarkers, Tumor - analysis; Cancer therapies; Cell adhesion & migration; Cell Line, Tumor; Cell surface; Chemotherapy; Clinical significance; CTCs; Epithelial-mesenchymal transition; Family medical history; Female; Genotype & phenotype; Humans; Male; Medical diagnosis; Medical imaging; Membrane Proteins - metabolism; Mesenchyme; Metastasis; Microfluidic Analytical Techniques; Microfluidics; Middle Aged; Neoplastic Cells, Circulating - pathology; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Pancreatic Intraductal Neoplasms - diagnosis; Pancreatic Intraductal Neoplasms - pathology; Pancreatic Intraductal Neoplasms - therapy; Patients; Phenotypes; R&D; Research & development; Tumor cells; Tumors; Vimentin; Vimentin - metabolism; China; Biomarker; EpCAM; Pancreatic ductal adenocarcinoma; CK; IPMN; EMT; CA19-9; Epithelial-mesenchymal transition; CTC; PDAC; CAFs; TGF-β; CTCs

The identification of circulating tumor cells (CTCs) relies on epithelial tumor cell markers. In the present study, we aimed to determine whether cell-surface vimentin could be a biomarker to isolate CTCs in pancreatic ductal adenocarcinoma (PDAC). Vimentin was identified as highly expressed on the...