European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis

• Published in: European journal of nuclear medicine and molecular imaging Vol. 40; no. 2; pp. 213 - 227
• Main Authors: Varrone, Andrea, Dickson, John C., Tossici-Bolt, Livia, Sera, Terez, Asenbaum, Susanne, Booij, Jan, Kapucu, Ozlem L., Kluge, Andreas, Knudsen, Gitte M., Koulibaly, Pierre Malick, Nobili, Flavio, Pagani, Marco, Sabri, Osama, Vander Borght, Thierry, Van Laere, Koen, Tatsch, Klaus
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.01.2013; Springer Nature B.V
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Brain - diagnostic imaging; Brain - pathology; Brain Mapping; Calibration; Cardiology; Case-Control Studies; Databases, Factual; Dementia - diagnosis; Dementia - diagnostic imaging; Diagnostic tests; Dopamine Plasma Membrane Transport Proteins - metabolism; Drug therapy; Female; Gender differences; Humans; Imaging; Iodine Radioisotopes - pharmacology; Male; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Models, Statistical; Nuclear Medicine; Nuclear Medicine - methods; Oncology; Original Article; Orthopedics; Parkinsonian Disorders - diagnosis; Parkinsonian Disorders - diagnostic imaging; Radiology; Reference Values; Sex Factors; Tomography, Emission-Computed, Single-Photon - methods; Tropanes - pharmacology; Europe; Database; Dopamine transporter; Age effects; Scatter correction; SPECT; Gender difference

Purpose Dopamine transporter (DAT) imaging with [ 123 I]FP-CIT (DaTSCAN) is an established diagnostic tool in parkinsonism and dementia. Although qualitative assessment criteria are available, DAT quantification is important for research and for completion of a diagnostic evaluation. One critical as...