Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children's Oncology Group AALL0434 Methotrexate Randomization

• Published in: Journal of clinical oncology Vol. 36; no. 29; pp. 2926 - 2934
• Main Authors: Winter, Stuart S, Dunsmore, Kimberly P, Devidas, Meenakshi, Wood, Brent L, Esiashvili, Natia, Chen, Zhiguo, Eisenberg, Nancy, Briegel, Nikki, Hayashi, Robert J, Gastier-Foster, Julie M, Carroll, Andrew J, Heerema, Nyla A, Asselin, Barbara L, Gaynon, Paul S, Borowitz, Michael J, Loh, Mignon L, Rabin, Karen R, Raetz, Elizabeth A, Zweidler-Mckay, Patrick A, Winick, Naomi J, Carroll, William L, Hunger, Stephen P
• Format: Journal Article
• Language: English
• Published: United States American Society of Clinical Oncology 10.10.2018
• Subjects: Adolescent; Adult; Antimetabolites, Antineoplastic - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Asparaginase - administration & dosage; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Leucovorin - administration & dosage; Male; Methotrexate - administration & dosage; ORIGINAL REPORTS; Polyethylene Glycols - administration & dosage; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality; Young Adult

Early intensification with methotrexate (MTX) is a key component of acute lymphoblastic leukemia (ALL) therapy. Two different approaches to MTX intensification exist but had not been compared in T-cell ALL (T-ALL): the Children's Oncology Group (COG) escalating dose intravenous MTX without leuc...