Identification of 5′ AMP-activated Kinase as a Target of Reactive Aldehydes during Chronic Ingestion of High Concentrations of Ethanol - Shearn, Colin T.; Backos, Donald S.; Orlicky, David J.; Smathers-McCullough, Rebecca L.; Petersen, Dennis R. (The Journal of biological chemistry, 2014)
Keywords: Alcohol; Aldehydes - metabolism; Aldehydes - pharmacology; AMP-activated Kinase (AMPK); AMP-Activated Protein Kinases - chemistry; AMP-Activated Protein Kinases - metabolism; Animals; Central Nervous System Depressants - pharmacology; Cysteine Proteinase Inhibitors - pharmacology; Disease Models, Animal; Ethanol - pharmacology; Fatty Liver - enzymology; Hep G2 Cells; Humans; Lipid Peroxidation; Lipid Peroxidation - drug effects; Lipid Peroxidation - physiology; Lipids; Liver; Liver Diseases, Alcoholic - enzymology; Male; Mice; Mice, Inbred C57BL; Models, Chemical; Oxidative Stress; Oxidative Stress - drug effects; Oxidative Stress - physiology; Phosphorylation - drug effects; Phosphorylation - physiology; Protein Carbonylation - drug effects; Protein Carbonylation - physiology; Signal Transduction - drug effects; Signal Transduction - physiology; Alcohol; AMP-activated Kinase (AMPK); Oxidative Stress; Lipid Peroxidation; Liver