The Role of the Medial Prefrontal Cortex in Spatial Margin of Safety Calculations

• Published in: The Journal of neuroscience Vol. 44; no. 34; p. e1162222024
• Main Authors: Qi, Song, Cross, Logan, Wise, Toby, Sui, Xin, O’Doherty, John, Mobbs, Dean
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 21.08.2024
• Subjects: Adult; Amygdala; Avoidance Learning - physiology; Brain Mapping; Coupling; Data analysis; Decision making; Decision Making - physiology; Female; Functional magnetic resonance imaging; Humans; Magnetic Resonance Imaging; Male; Mental task performance; Multivariate analysis; Neostriatum; Outliers (statistics); Pattern analysis; Prefrontal cortex; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - physiology; Safety; Space Perception - physiology; Threat evaluation; Young Adult; margin of safety; avoidance; predictability; ventromedial prefrontal cortex
• ISSN: 0270-6474; 1529-2401; 1529-2401
• DOI: 10.1523/JNEUROSCI.1162-22.2024

Naturalistic observations show that animals pre-empt danger by moving to locations that increase their success in avoiding future threats. To test this in humans, we created a spatial margin of safety (MOS) decision task that quantifies pre-emptive avoidance by measuring the distance subjects place themselves to safety when facing different threats whose attack locations vary in predictability. Behavioral results show that human participants place themselves closer to safe locations when facing threats that attack in spatial locations with more outliers. Using both univariate and multivariate pattern analysis (MVPA) on fMRI data collected during a 2 h session on participants of both sexes, we demonstrate a dissociable role for the vmPFC in MOS-related decision-making. MVPA results revealed that the posterior vmPFC encoded for more unpredictable threats with univariate analyses showing a functional coupling with the amygdala and hippocampus. Conversely, the anterior vmPFC was more active for the more predictable attacks and showed coupling with the striatum. Our findings converge in showing that during pre-emptive danger, the anterior vmPFC may provide a safety signal, possibly via foreseeable outcomes, while the posterior vmPFC drives unpredictable danger signals.