Next-Day Effects of Ramelteon (8 mg), Zopiclone (7.5 mg), and Placebo on Highway Driving Performance, Memory Functioning, Psychomotor Performance, and Mood in Healthy Adult Subjects

• Published in: Sleep (New York, N.Y.) Vol. 34; no. 10; pp. 1327 - 1334
• Main Authors: Mets, Monique A.J., de Vries, Juna M., de Senerpont Domis, Lieke M., Volkerts, Edmund R., Olivier, Berend, Verster, Joris C.
• Format: Journal Article
• Language: English
• Published: United States Associated Professional Sleep Societies, LLC 01.10.2011
• Subjects: Adult; Affect - drug effects; Automobile Driving - psychology; Azabicyclo Compounds - pharmacology; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypnotics and Sedatives - pharmacology; Indenes - pharmacology; Male; Memory - drug effects; Middle Aged; Neuropsychological Tests; Next-Day Effects of Ramelteon (8 mg), Zolpidem (7.5 mg), and Placebo; Piperazines - pharmacology; Psychomotor Performance - drug effects; Time Factors; Young Adult; Driving; ramelteon; memory; balance; zopiclone; psychomotor

To evaluate the next-morning residual effects of ramelteon (8 mg), zopiclone (7.5 mg), and placebo on driving performance, memory functioning, psychomotor performance, and mood in healthy adult subjects following bedtime dosing and a middle of the night awakening. Single-center, randomized, double-b...