2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation

• Published in: Bioorganic & medicinal chemistry letters Vol. 22; no. 22; pp. 6867 - 6870
• Main Authors: Chen, Yingyi, Wen, Donghua, Huang, Zhimin, Huang, Min, Luo, Yu, Liu, Bin, Lu, Han, Wu, Yingli, Peng, Yuefeng, Zhang, Jian
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.11.2012; Elsevier
• Subjects: Benzamides - chemical synthesis; Benzamides - chemistry; Benzamides - metabolism; Binding Sites; Biological and medical sciences; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Cysteine Endopeptidases; drugs; Endopeptidases - chemistry; Endopeptidases - metabolism; Humans; Life Sciences & Biomedicine; Medical sciences; men; Molecular Docking Simulation; mortality; para-Aminobenzoates - chemical synthesis; para-Aminobenzoates - chemistry; para-Aminobenzoates - metabolism; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Physical Sciences; prostatic neoplasms; Protease Inhibitors - chemical synthesis; Protease Inhibitors - chemistry; Protease Inhibitors - metabolism; Protein Binding; proteinases; Science & Technology; screening; SENP1; Structure-Activity Relationship; structure-activity relationships; Virtual screening; Virtual screening; Structure–activity relationship; SENP1; ENZYME; Structure-activity relationship; SMALL-MOLECULE INHIBITORS; SENTRIN; SUMOYLATION; PROBES; Structure activity relation; Chlorine Organic compounds; Inhibitor; Chemical synthesis; Biological activity

Chemical structure of 2-(4-chlorophenyl)-2-oxoethyl 4-(3-(benzyloxy)benzamido)benzoate, a Sentrin-specific protease 1 (SENP1) inhibitor. Prostate cancer is one of the most prevalent types of malignant cancers in men and has a high mortality rate among all male cancers. Previous studies have demonstr...