2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation - Chen, Yingyi; Wen, Donghua; Huang, Zhimin; Huang, Min; Luo, Yu; Liu, Bin; Lu, Han; Wu, Yingli; Peng, Yuefeng; Zhang, Jian (Bioorganic & medicinal chemistry letters, 2012)
Keywords: Benzamides - chemical synthesis; Benzamides - chemistry; Benzamides - metabolism; Binding Sites; Biological and medical sciences; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Cysteine Endopeptidases; drugs; Endopeptidases - chemistry; Endopeptidases - metabolism; Humans; Life Sciences & Biomedicine; Medical sciences; men; Molecular Docking Simulation; mortality; para-Aminobenzoates - chemical synthesis; para-Aminobenzoates - chemistry; para-Aminobenzoates - metabolism; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Physical Sciences; prostatic neoplasms; Protease Inhibitors - chemical synthesis; Protease Inhibitors - chemistry; Protease Inhibitors - metabolism; Protein Binding; proteinases; Science & Technology; screening; SENP1; Structure-Activity Relationship; structure-activity relationships; Virtual screening; Virtual screening; Structure–activity relationship; SENP1; ENZYME; Structure-activity relationship; SMALL-MOLECULE INHIBITORS; SENTRIN; SUMOYLATION; PROBES; Structure activity relation; Chlorine Organic compounds; Inhibitor; Chemical synthesis; Biological activity