One single dose of etomidate negatively influences adrenocortical performance for at least 24 h in children with meningococcal sepsis

• Published in: Intensive care medicine Vol. 34; no. 1; pp. 163 - 168
• Main Authors: den Brinker, Marieke, Hokken-Koelega, Anita C. S., Hazelzet, Jan A., de Jong, Frank H., Hop, Wim C. J., Joosten, Koen F. M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.01.2008; Springer; Springer Nature B.V
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthesiology; Biological and medical sciences; Brief Report; Critical Care Medicine; Emergency and intensive care: infection, septic shock; Emergency Medicine; Enzymes; Glucose; Hormones; Hospitals; Intensive; Intensive care; Intensive care medicine; Intubation; Medical sciences; Medicine; Medicine & Public Health; Mortality; Pain Medicine; Pediatrics; Pharmacology. Drug treatments; Pneumology/Respiratory System; Respiratory system; Sepsis; Steroids; Netherlands; Critical illness; Adrenal insufficiency; Child; Etomidate; Meningococcal disease; Endocrinopathy; Human; Imidazole derivatives; Intensive care; Single dose; Meningococcal disease, Child; Etomidate, Critical illness; Infection; Sepsis syndrome; General anesthetic; Adrenal gland diseases; Bacteriosis; Resuscitation

Objective To investigate the effect of one single bolus of etomidate used for intubation on adrenal function in children with meningococcal sepsis. Design Retrospective study conducted between 1997 and 2004. Setting University-affiliated paediatric intensive care unit (PICU). Patients and participan...