Adipocyte Lipolysis-stimulated Interleukin-6 Production Requires Sphingosine Kinase 1 Activity

• Published in: The Journal of biological chemistry Vol. 289; no. 46; pp. 32178 - 32185
• Main Authors: Zhang, Wenliang, Mottillo, Emilio P., Zhao, Jiawei, Gartung, Allison, VanHecke, Garrett C., Lee, Jen-Fu, Maddipati, Krishna R., Xu, Haiyan, Ahn, Young-Hoon, Proia, Richard L., Granneman, James G., Lee, Menq-Jer
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.11.2014; American Society for Biochemistry and Molecular Biology
• Subjects: 3T3-L1 Cells; Adipocytes - cytology; Adipocytes - metabolism; Adipose Tissue - metabolism; Adipose Tissue - pathology; Animals; Inflammation - metabolism; Interleukin-6 - metabolism; Lipids; Lipolysis; Male; MAP Kinase Kinase 4 - metabolism; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor) - metabolism; RNA, Small Interfering - metabolism; Signal Transduction; Sphingolipids - chemistry; Tandem Mass Spectrometry; Interleukin 6 (IL-6); Beta 3 Adrenergic Receptor; c-Jun N-terminal Kinase (JNK); AP1 Transcription Factor (AP-1); Inflammation; Adipose Tissue; Hormone-sensitive Lipase; Lipolysis; Sphingosine Kinase

Adipocyte lipolysis can increase the production of inflammatory cytokines such as interleukin-6 (IL-6) that promote insulin resistance. However, the mechanisms that link lipolysis with inflammation remain elusive. Acute activation of β3-adrenergic receptors (ADRB3) triggers lipolysis and up-regulate...