Monoclonal Antibodies Counteract Opioid-Induced Behavioral and Toxic Effects in Mice and Rats

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 375; no. 3; pp. 469 - 477
• Main Authors: Baehr, Carly, Kelcher, April Huseby, Khaimraj, Aaron, Reed, Dana E., Pandit, Sujata G., AuCoin, David, Averick, Saadyah, Pravetoni, Marco
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2020; The American Society for Pharmacology and Experimental Therapeutics
• Subjects: Analgesics, Opioid - immunology; Analgesics, Opioid - toxicity; Animals; Antibodies, Monoclonal - immunology; Behavior, Animal; Drug Discovery and Translational Medicine; Female; Immunization; Male; Mice; Rats; Ab; sKLH; F; HRP; IL-4; M; mAb; GC-MS; BSA; OXY; LC-MS; PE; 6-AM; BLI; OUD
• ISSN: 0022-3565; 1521-0103; 1521-0103
• DOI: 10.1124/jpet.120.000124

Monoclonal antibodies (mAbs) and vaccines have been proposed as medical countermeasures to treat opioid use disorder (OUD) and prevent opioid overdose. In contrast to current pharmacotherapies (e.g., methadone, buprenorphine, naltrexone, and naloxone) for OUD and overdose, which target brain opioid...