A reciprocal feedback loop between HIF-1α and HPIP controls phenotypic plasticity in breast cancer cells

• Published in: Cancer letters Vol. 526; pp. 12 - 28
• Main Authors: Khumukcham, Saratchandra Singh, Penugurti, Vasudevarao, Soni, Anita, Uppala, Veena, Hari, Kishore, Jolly, Mohit Kumar, Dwivedi, Anju, Salam PK, Abdul, Padala, Chiranjeevi, Mukta, Srinivasulu, Bhopal, Triveni, Manavathi, Bramanandam
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.02.2022; Elsevier Limited
• Subjects: Animals; Antibodies; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Carbon dioxide; Cell growth; Cell Line, Tumor; Cell migration; Cell proliferation; Cell survival; Feedback; Female; Gelatinase B; Genes; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factor 1a; Intracellular Signaling Peptides and Proteins - metabolism; Kinases; Leukemia; Mathematical models; Medical prognosis; Metastases; Metastasis; Mice; Molecular modelling; Phenotype; Phenotypes; Phenotypic plasticity; Plasmids; Proteins; Signal recognition particle; Therapeutic targets; Tumor microenvironment; Tumors; Warburg effect; United States > US; India; Cell proliferation; Hypoxia; Metastasis; Tumor microenvironment; Warburg effect
• ISSN: 0304-3835; 1872-7980; 1872-7980
• DOI: 10.1016/j.canlet.2021.11.002

While phenotypic plasticity is a critical factor contributing to tumor heterogeneity, molecular mechanisms underlying this process are largely unknown. Here we report that breast cancer cells display phenotypic diversity in response to hypoxia or normoxia microenvironments by operating a reciprocal...