Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 118; no. 37; pp. 1 - 9
• Main Authors: Teruya, Takayuki, Chen, Yung-Ju, Kondoh, Hiroshi, Fukuji, Yasuhide, Yanagida, Mitsuhiro
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 14.09.2021
• Subjects: Adenosine triphosphate; Aged; Aging; Amino acids; Ammonium; Antioxidants; ATP; Biological Sciences; Biomarkers - blood; Brain; Brain - metabolism; Carnitine; Case-Control Studies; Central nervous system; Cognition; Cognitive ability; Dementia; Dementia - blood; Dementia - pathology; Dementia disorders; Erythrocytes; Glutathione; Humans; Liquid chromatography; Markers; Mass spectroscopy; Metabolites; Metabolome; Metabolomics; Methionine; NADP; Neuropsychological Tests; Neurotoxins; Quinolinic acid; Signal Transduction; Toxins; ergothioneine; dementia; Alzheimer’s disease; antioxidants; trimethyl-ammonium compounds

Dementia is caused by factors that damage neurons. We quantified small molecular markers in whole blood of dementia patients, using nontargeted liquid chromatography–mass spectroscopy (LC-MS). Thirty-three metabolites, classified into five groups (A to E), differed significantly in dementia patients...