Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate

• Published in: Cancer research (Chicago, Ill.) Vol. 68; no. 16; pp. 6797 - 6802
• Main Authors: Fu, Vivian X, Dobosy, Joseph R, Desotelle, Joshua A, Almassi, Nima, Ewald, Jonathan A, Srinivasan, Rajini, Berres, Mark, Svaren, John, Weindruch, Richard, Jarrard, David F
• Format: Journal Article
• Language: English
• Published: United States 15.08.2008
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Aging - genetics; Animals; Binding Sites; CCCTC-Binding Factor; Chromatin Immunoprecipitation; DNA Methylation; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Epigenesis, Genetic; Epithelial Cells - metabolism; Epithelial Cells - pathology; Female; Fluorescent Antibody Technique; Genomic Imprinting; Humans; Insulin-Like Growth Factor II - genetics; Male; Mice; Mice, Inbred C57BL; Middle Aged; Polymerase Chain Reaction; Prostate - metabolism; Prostate - pathology; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Repressor Proteins - genetics; Repressor Proteins - metabolism; RNA, Long Noncoding; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA, Untranslated - genetics

Loss of imprinting (LOI) is an epigenetic alteration involving loss of parental origin-specific expression at normally imprinted genes. A LOI for Igf2, a paracrine growth factor, is important in cancer progression. Epigenetic modifications may be altered by environmental factors. However, is not kno...