C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6′-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-κB Activation

• Published in: The Journal of biological chemistry Vol. 289; no. 43; pp. 30052 - 30062
• Main Authors: Zhao, Xue-Qiang, Zhu, Le-Le, Chang, Qing, Jiang, Changying, You, Yun, Luo, Tianming, Jia, Xin-Ming, Lin, Xin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.10.2014; American Society for Biochemistry and Molecular Biology
• Subjects: Adaptor Proteins, Signal Transducing - deficiency; Adaptor Proteins, Signal Transducing - metabolism; Adjuvants, Immunologic - pharmacology; Animals; B-Cell CLL-Lymphoma 10 Protein; CARD Signaling Adaptor Proteins - deficiency; CARD Signaling Adaptor Proteins - metabolism; Caspases - deficiency; Caspases - metabolism; Cord Factors - pharmacology; Cytokines - biosynthesis; Gene Expression Regulation - drug effects; Humans; Immunology; Lectins, C-Type - deficiency; Lectins, C-Type - genetics; Lectins, C-Type - metabolism; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice, Inbred C57BL; Models, Biological; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; Neoplasm Proteins - deficiency; Neoplasm Proteins - metabolism; NF-kappa B - metabolism; NFATC Transcription Factors - metabolism; Promoter Regions, Genetic - genetics; Protein Multimerization - drug effects; Protein Subunits - metabolism; Receptors, Immunologic - deficiency; Receptors, Immunologic - metabolism; Signal Transduction - drug effects; Transcription Factor RelA - metabolism; Lectin; Signal Transduction; Innate Immunity; NF-κB Transcription Factor; NF-kappa B (NF-κB)

Previous studies indicate that both Dectin-3 (also called MCL or Clec4d) and Mincle (also called Clec4e), two C-type lectin receptors, can recognize trehalose 6,6′-dimycolate (TDM), a cell wall component from mycobacteria, and induce potent innate immune responses. Interestingly, stimulation of Dect...