Chinchilla models of selective cochlear hair cell loss

• Published in: Hearing research Vol. 174; no. 1; pp. 230 - 238
• Main Authors: McFadden, Sandra L, Ding, Dalian, Jiang, Haiyan, Woo, Jenifer M, Salvi, Richard J
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.12.2002; Elsevier
• Subjects: Aminoglycoside antibiotic; Animals; Anti-Bacterial Agents - administration & dosage; Biological and medical sciences; Body Weight - drug effects; Cell Death; Chinchilla; Cochlea - drug effects; Cochlea - pathology; Cochlea - physiology; Diuretics - administration & dosage; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Drug toxicity and drugs side effects treatment; Ethacrynic Acid - administration & dosage; Free radical; Gentamicins - administration & dosage; Hair Cells, Auditory - drug effects; Hair Cells, Auditory - pathology; Hair Cells, Auditory - physiology; Hair Cells, Vestibular - drug effects; Hair Cells, Vestibular - physiology; Hearing loss; Inner ear pathology; Loop diuretic; Medical sciences; Ototoxicity; Pharmacology. Drug treatments; Toxicity: respiratory system, ent, stomatology; Loop diuretic; Aminoglycoside antibiotic; OHC, outer hair cell; GM, gentamicin sulfate; IHC, inner hair cell; AAB, aminoglycoside antibiotics; EA, ethacrynic acid; Inner ear pathology; ROS, reactive oxygen species; Free radical; Ototoxicity; Hearing loss; Cell function; Toxicity; Gentamicin; Auditory disorder; Etacrynic acid; Chinchilla; Organ of hearing; Diuretic; ENT disease; Vestibular system; Hair cell of the ear; Internal ear disease; Rodentia; Vertebrata; Antibiotic; Mammalia; Cell death; Aminoglycoside; Cochlea

Although it is well known that ethacrynic acid (EA) can enhance gentamicin (GM) ototoxicity, there has been no systematic study of the relationship between dosing parameters and inner ear pathology. We examined the effects of two parameters, GM dose and time delay between GM and EA administration, o...