Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance - Brekk, Oeystein Roed; Honey, Jonathan R.; Lee, Seungil; Hallett, Penelope J.; Isacson, Ole (Proceedings of the National Academy of Sciences - PNAS, 2020)
Keywords: Aged; Aged, 80 and over; alpha-Synuclein - metabolism; Animals; Astrocytes; Astrocytes - metabolism; Astrocytes - pathology; Biological Sciences; Case-Control Studies; Central nervous system; Cohort Studies; Disease Models, Animal; Dopamine receptors; Dopaminergic Neurons - metabolism; Dopaminergic Neurons - pathology; Female; Fluorescent indicators; Glucosylceramidase; Glucosylceramidase - genetics; Glucosylceramidase - metabolism; Glycolipids - metabolism; Glycoproteins; Healthy Volunteers; Homeostasis; Humans; Inflammation; Lipids; Localization; Male; Melanoma; Membrane Glycoproteins - metabolism; Mesencephalon; Metabolites; Metastases; Mice; Microglia; Microglia - metabolism; Microglia - pathology; Middle Aged; Movement disorders; Neurodegenerative diseases; Neuronal-glial interactions; Neurons; Parkinson Disease - pathology; Parkinson's disease; Pathogenesis; Protein B; Signaling; Substantia nigra; Substantia Nigra - cytology; Substantia Nigra - metabolism; Substantia Nigra - pathology; Triglycerides; Triglycerides - metabolism; lipids; astrocytes; neurons; Parkinson’s disease; glucocerebrosidase