Chemotherapy of human African trypanosomiasis: current and future prospects

• Published in: Trends in parasitology Vol. 19; no. 11; pp. 488 - 494
• Main Author: Fairlamb, Alan H.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2003
• Subjects: African trypanosomiasis; Animals; Drug Resistance; Humans; Parasitic Sensitivity Tests; Treatment Outcome; Trypanocidal Agents - pharmacology; Trypanocidal Agents - therapeutic use; Trypanosoma; Trypanosoma brucei gambiense - drug effects; Trypanosomiasis, African - drug therapy

Three of the four currently approved drugs for the treatment of African trypanosomiasis (sleeping sickness) were developed over 50 years ago. All of the current therapies are unsatisfactory for various reasons, including unacceptable toxicity, poor efficacy, undesirable route of administration, and...