Expression of a Functional Mx1 Protein Is Essential for the Ability of RIG-I Agonist Prophylaxis to Provide Potent and Long-Lasting Protection in a Mouse Model of Influenza A Virus Infection

• Published in: Viruses Vol. 14; no. 7; p. 1547
• Main Authors: Schwab, Lara S. U, Villalón-Letelier, Fernando, Tessema, Melkamu B, Londrigan, Sarah L, Brooks, Andrew G, Hurt, Aeron, Coch, Christoph, Zillinger, Thomas, Hartmann, Gunther, Reading, Patrick C
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 15.07.2022; MDPI
• Subjects: Agonists; Analysis; Animal models; Animals; Care and treatment; Dengue fever; Diagnosis; Disease prevention; Fibroblasts; Immunocompromised host; Inbreeding; Infections; Influenza; Influenza A; innate immunity; Interferon; Intravenous administration; mouse model; Myxoma; Myxovirus resistance proteins; Prophylaxis; Proteins; RIG-I; RNA viruses; Rodents; Severe acute respiratory syndrome coronavirus 2; Transcription activation; Viruses; Australia; United States > US; Melbourne Victoria Australia

RIG-I is an innate sensor of RNA virus infection and its activation induces interferon-stimulated genes (ISGs). In vitro studies using human cells have demonstrated the ability of synthetic RIG-I agonists (3pRNA) to inhibit IAV replication. However, in mouse models of IAV the effectiveness of 3pRNA...