Identification of Differentially Expressed Proteins in Direct Expressed Prostatic Secretions of Men with Organ-confined Versus Extracapsular Prostate Cancer

• Published in: Molecular & cellular proteomics Vol. 11; no. 12; pp. 1870 - 1884
• Main Authors: Kim, Yunee, Ignatchenko, Vladimir, Yao, Cindy Q., Kalatskaya, Irina, Nyalwidhe, Julius O., Lance, Raymond S., Gramolini, Anthony O., Troyer, Dean A., Stein, Lincoln D., Boutros, Paul C., Medin, Jeffrey A., Semmes, O. John, Drake, Richard R., Kislinger, Thomas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2012; The American Society for Biochemistry and Molecular Biology
• Subjects: 14-3-3 Proteins - analysis; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Exonucleases - analysis; Exoribonucleases; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins - analysis; Isotope Labeling; Male; Oncogene Proteins - analysis; Prostate - metabolism; Prostate-Specific Antigen - metabolism; Prostatic Neoplasms - metabolism; Prostatic Secretory Proteins - analysis; Prostatic Secretory Proteins - urine; Protein Array Analysis; Protein Deglycase DJ-1; Proteome - analysis; Tissue Inhibitor of Metalloproteinase-1 - analysis; Transglutaminases - analysis

Current protocols for the screening of prostate cancer cannot accurately discriminate clinically indolent tumors from more aggressive ones. One reliable indicator of outcome has been the determination of organ-confined versus nonorgan-confined disease but even this determination is often only made f...