Role of Conserved Glycine in Zinc-dependent Medium Chain Dehydrogenase/Reductase Superfamily

• Published in: The Journal of biological chemistry Vol. 287; no. 23; pp. 19429 - 19439
• Main Authors: Tiwari, Manish Kumar, Singh, Raushan Kumar, Singh, Ranjitha, Jeya, Marimuthu, Zhao, Huimin, Lee, Jung-Kul
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2012; American Society for Biochemistry and Molecular Biology
• Subjects: Alcohol Dehydrogenase - chemistry; Alcohol Dehydrogenase - genetics; Alcohol Dehydrogenase - metabolism; Amino Acid Motifs; Coordination Geometry; Density Functional Theory; Electron Spin Resonance Spectroscopy; Enzyme Catalysis; Enzyme Mechanisms; Enzymology; Fungal Proteins - chemistry; Fungal Proteins - genetics; Fungal Proteins - metabolism; Glycine - chemistry; Glycine - genetics; Glycine - metabolism; Metalloenzymes; Molecular Modeling; Mutagenesis; Mutagenesis, Site-Directed; Neurospora crassa - enzymology; Neurospora crassa - genetics; Protein Structure, Tertiary; Zinc - chemistry; Zinc - metabolism; Enzyme Mechanisms; Molecular Modeling; Mutagenesis; Enzyme Catalysis; Density Functional Theory; Coordination Geometry; Metalloenzymes

The medium-chain dehydrogenase/reductase (MDR) superfamily consists of a large group of enzymes with a broad range of activities. Members of this superfamily are currently the subject of intensive investigation, but many aspects, including the zinc dependence of MDR superfamily proteins, have not ye...