Cardiac Autonomic Dysfunction Effects From Particulate Air Pollution and Protection by Dietary Methyl Nutrients and Metabolic Polymorphisms

• Published in: Circulation (New York, N.Y.) Vol. 117; no. 14; pp. 1802 - 1809
• Main Authors: Baccarelli, Andrea, Cassano, Patricia A., Litonjua, Augusto, Park, Sung Kyun, Suh, Helen, Sparrow, David, Vokonas, Pantel, Schwartz, Joel
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 08.04.2008
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Blood and lymphatic vessels; Boston - epidemiology; Cardiology. Vascular system; Cardiotonic Agents - pharmacology; Cardiovascular system; Case-Control Studies; Diet; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Glycine Hydroxymethyltransferase - genetics; Glycine Hydroxymethyltransferase - physiology; Heart Conduction System - drug effects; Heart Conduction System - physiopathology; Heart Rate - drug effects; Heart Rate - genetics; Humans; Male; Medical sciences; Meteorological Concepts; Methionine; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Methylenetetrahydrofolate Reductase (NADPH2) - physiology; Particulate Matter - toxicity; Pharmacology. Drug treatments; Polymorphism, Single Nucleotide; Risk Factors; Vasodilator agents. Cerebral vasodilators; Vitamin B Complex; Boston; Heart rate; Senescence; Autonomic nervous system; nervous system, autonomic; Cardiovascular disease; Air pollution; aging; Metabolism; Epidemiology; Polymorphism

Background— Particulate air pollution is associated with cardiovascular mortality and morbidity. To help identify mechanisms of action and protective/susceptibility factors, we evaluated whether the effect of particulate matter <2.5 μm in aerodynamic diameter (PM 2.5 ) on heart rate variability w...