Inhibition of 5-Lipoxygenase Selectively Triggers Disruption of c-Myc Signaling in Prostate Cancer Cells

• Published in: The Journal of biological chemistry Vol. 290; no. 8; pp. 4994 - 5006
• Main Authors: Sarveswaran, Sivalokanathan, Chakraborty, Debrup, Chitale, Dhananjay, Sears, Rosalie, Ghosh, Jagadananda
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.02.2015; American Society for Biochemistry and Molecular Biology
• Subjects: 5-Lipoxygenase; 5-Lipoxygenase-Activating Protein Inhibitors - pharmacology; Apoptosis; Apoptosis - drug effects; Arachidonate 5-Lipoxygenase - genetics; Arachidonate 5-Lipoxygenase - metabolism; Cell Biology; Cell Line, Tumor; Down-Regulation - drug effects; Down-Regulation - genetics; Eicosanoid; Gene Expression Regulation, Enzymologic - drug effects; Gene Expression Regulation, Enzymologic - genetics; Gene Expression Regulation, Neoplastic - drug effects; Gene Expression Regulation, Neoplastic - genetics; Humans; Indoles - pharmacology; Lipoxygenase Inhibitors - pharmacology; Lipoxygenase Pathway; Male; MK591; Myc (c-Myc); Prostate Cancer; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - enzymology; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Proto-Oncogene Proteins c-myc - biosynthesis; Proto-Oncogene Proteins c-myc - genetics; Quinolines - pharmacology; Signal Transduction - drug effects; Transcription, Genetic - drug effects; Transcription, Genetic - genetics; MK591; Eicosanoid; 5-Lipoxygenase; Prostate Cancer; Lipoxygenase Pathway; Apoptosis; Myc (c-Myc)

Myc is up-regulated in almost all cancer types and is the subject of intense investigation because of its pleiotropic effects controlling a broad spectrum of cell functions. However, despite its recognition as a stand-alone molecular target, development of suitable strategies to block its function i...