Brain development in male rats subjected to early weaning and treated with diet containing flour or flaxseed oil after 21 days until 60 days

The precocious interruption of lactation is a prime factor for developmental plasticity. Here we analyzed whether flour or flaxseed oil treatment contributes to body and brain mass in male rats subjected to early weaning. Pups were weaned for separation from their mother at 14 (early weaning, EW) an...

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Published inJournal of developmental origins of health and disease Vol. 6; no. 4; pp. 268 - 271
Main Authors Pessanha, C. R., da Camara Boueri, B. Ferolla, da Costa, L. Rodrigues, Ferreira, M. Rocha, Melo, H. Saldanha, de Abreu, M. Duque Coutinho, Pessoa, L. Rozeno, da Silva, P. C. Alves, Pereira, A. D’Avila, Ribeiro, D. Cavalcante, de Meneses, J. Azevedo, da Costa, C. A. Soares, Boaventura, G. T.
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 01.08.2015
Subjects
Animal cognition
Animals
Brain - growth & development
Brief Report
Cell adhesion & migration
Diet
Fatty acids
Fatty Acids, Essential
Flax
Laboratory animals
Linseed Oil
Male
Malnutrition
Nutrition
Rats, Wistar
Rodents
Soybeans
Vegetable oils
Weaning
Brazil
United States > US
flaxseed
rat
brain
early weaning
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Summary:The precocious interruption of lactation is a prime factor for developmental plasticity. Here we analyzed whether flour or flaxseed oil treatment contributes to body and brain mass in male rats subjected to early weaning. Pups were weaned for separation from their mother at 14 (early weaning, EW) and 21 days (control, C). At 21 days, some of the pups were evaluated (C21 v. EW21). After 21 days, control pups (C60) were fed a control diet. EW pups were divided into those fed a control diet (EWC60), those given flaxseed flour (EWFF60), and those given flaxseed oil (EWFO60) until 60 days. EW21 showed lower body and absolute brain mass and higher relative brain mass. At 60 days, EWC60 and EWFO60 had lower body mass. With regard to relative brain mass, EWC60 was heavier; EWFO60 had lower values compared with EWC60 and higher values compared with C60 and EWFF60. These results indicated that flaxseed flour, in comparison with flaxseed oil, contributes to brain development after EW.
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ISSN:2040-1744
2040-1752
DOI:10.1017/S2040174415001087