Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance

• Published in: Journal of lipid research Vol. 43; no. 5; pp. 742 - 750
• Main Authors: Madsen, Lise, Guerre-Millo, Michéle, Flindt, Esben N, Berge, Kjetil, Tronstad, Karl Johan, Bergene, Elin, Sebokova, Elena, Rustan, Arild C, Jensen, Jørgen, Mandrup, Susanne, Kristiansen, Karsten, Klimes, Iwar, Staels, Bart, Berge, Rolf K
• Format: Journal Article
• Language: English
• Published: United States Elsevier 01.05.2002
• Subjects: Adipose Tissue - anatomy & histology; Adipose Tissue - drug effects; Animals; Antioxidants - pharmacology; CPT-I; CPT-II; Dietary Fats - antagonists & inhibitors; Dietary Fats - pharmacology; fatty acid analogues; fatty acid oxidation; Insulin - blood; insulin action; Insulin Resistance - physiology; Kinetics; Male; Mitochondria, Liver - drug effects; Mitochondria, Liver - metabolism; Obesity - genetics; Obesity - prevention & control; PPAR; Rats; Rats, Wistar; Rats, Zucker; Receptors, Cytoplasmic and Nuclear - drug effects; Receptors, Cytoplasmic and Nuclear - metabolism; Reference Values; Sulfides - pharmacology; Transcription Factors - drug effects; Transcription Factors - metabolism; Triglycerides - blood

Tetradecylthioacetic acid (TTA) is a non-beta-oxidizable fatty acid analog, which potently regulates lipid homeostasis. Here we evaluate the ability of TTA to prevent diet-induced and genetically determined adiposity and insulin resistance. In Wistar rats fed a high fat diet, TTA administration comp...