(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses

• Published in: Viruses Vol. 14; no. 10; p. 2154
• Main Authors: Filimonov, Aleksandr S., Yarovaya, Olga I., Zaykovskaya, Anna V., Rudometova, Nadezda B., Shcherbakov, Dmitriy N., Chirkova, Varvara Yu, Baev, Dmitry S., Borisevich, Sophia S., Luzina, Olga A., Pyankov, Oleg V., Maksyutov, Rinat A., Salakhutdinov, Nariman F.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 29.09.2022; MDPI
• Subjects: Acids; Antiviral activity; Antiviral agents; antiviral compound; Antiviral drugs; Chemical properties; Chemistry; Chromatography; Coronaviruses; COVID-19 vaccines; Dibenzofurans; Drugs; Enzymes; Fatalities; Glycoprotein S; Hemoglobin; Immunization; Influenza; main viral protease 3CLPro; molecular modeling; Molecular modelling; Pandemics; Pharmaceutical sciences; Potash; Potassium; Proteins; Severe acute respiratory syndrome coronavirus 2; Strains (organisms); surface glycoprotein S; Testing; Usnic acid; virus SARS-CoV-2; Viruses; Russia

In order to test the antiviral activity, a series of usnic acid derivatives were synthesized, including new, previously undescribed compounds. The activity of the derivatives against three strains of SARS-CoV-2 virus was studied. To understand the mechanism of antiviral action, the inhibitory activi...