Pharmacodynamic effects of standard dose prasugrel versus high dose clopidogrel in non-diabetic obese patients with coronary artery disease

• Published in: Thrombosis and haemostasis Vol. 111; no. 2; p. 258
• Main Authors: Darlington, Andrew, Tello-Montoliu, Antonio, Rollini, Fabiana, Ueno, Masafumi, Ferreiro, José Luis, Patel, Ronakkumar, Desai, Bhaloo, Guzman, Luis A, Bass, Theodore A, Angiolillo, Dominick J
• Format: Journal Article
• Language: English
• Published: Germany 01.02.2014
• Subjects: Aspirin - administration & dosage; Biomarkers - blood; Blood Platelets - drug effects; Blood Platelets - metabolism; Body Mass Index; Cell Adhesion Molecules - blood; Coronary Artery Disease - blood; Coronary Artery Disease - complications; Coronary Artery Disease - diagnosis; Coronary Artery Disease - drug therapy; Drug Therapy, Combination; Female; Florida; Humans; Male; Microfilament Proteins - blood; Middle Aged; Obesity - complications; Obesity - diagnosis; Phosphoproteins - blood; Phosphorylation; Piperazines - administration & dosage; Piperazines - adverse effects; Platelet Activation - drug effects; Platelet Adhesiveness - drug effects; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - adverse effects; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Receptors, Purinergic P2Y12 - blood; Receptors, Purinergic P2Y12 - drug effects; Thiophenes - administration & dosage; Thiophenes - adverse effects; Ticlopidine - administration & dosage; Ticlopidine - adverse effects; Ticlopidine - analogs & derivatives; Time Factors; Treatment Outcome; Florida; clopidogrel; coronary artery disease; prasugrel; obesity; Platelet function

Increased body weight is independently associated with impaired clopidogrel pharmacodynamic (PD) response. Prasugrel has more potent PD effects compared with clopidogrel, although its PD effects in obese patients are unknown. The aim of this prospective, randomised, study was to compare the PD effec...