Assessing Stress Induced by Fluid Shifts and Reduced Cerebral Clearance during Robotic-Assisted Laparoscopic Radical Prostatectomy under Trendelenburg Positioning (UroTreND Study)

• Published in: Methods and protocols Vol. 7; no. 2; p. 31
• Main Authors: Peschke, Tobias, Feuerecker, Matthias, Siegl, Daniel, Schicktanz, Nathalie, Stief, Christian, Zu Eulenburg, Peter, Choukér, Alexander, Buchheim, Judith-Irina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2024
• Subjects: Analysis; Anesthesia; Biomarkers; Blood-brain barrier; Brain damage; Cardiovascular system; Clinical trials; Cognition; Delirium; Ethylenediaminetetraacetic acid; General anesthesia; Heparan sulfate; Informed consent; Intracranial pressure; Laparoscopic surgery; Laparoscopy; Mechanical ventilation; Medical research; Medicine, Experimental; neurofilament light chain; neuromonitoring; neuronal damage; Neurons; Optic nerve; optic nerve sheet diameter; Participation; Patients; Physiology; Prostatectomy; Proteins; Remifentanil; robotic-assisted laparoscopic radical prostatectomy; Robotics; Saliva; single-molecule array; Sufentanil; Surgery; Ultrasonic imaging; Germany; neuromonitoring; neuronal damage; neurofilament light chain; robotic-assisted laparoscopic radical prostatectomy; optic nerve sheet diameter; single-molecule array

In addition to general anesthesia and mechanical ventilation, robotic-assisted laparoscopic radical prostatectomy (RALP) necessitates maintaining a capnoperitoneum and placing the patient in a pronounced downward tilt (Trendelenburg position). While the effects of the resulting fluid shift on the ca...