NF-κB Down-regulates Expression of the B-lymphoma Marker CD10 through a miR-155/PU.1 Pathway

• Published in: The Journal of biological chemistry Vol. 286; no. 3; pp. 1675 - 1682
• Main Authors: Thompson, Ryan C., Herscovitch, Melanie, Zhao, Ian, Ford, Tyler J., Gilmore, Thomas D.
• Format: Journal Article
• Language: English
• Published: 9650 Rockville Pike, Bethesda, MD 20814, U.S.A Elsevier Inc 21.01.2011; American Society for Biochemistry and Molecular Biology
• Subjects: B-cell Lymphoma; CD10; DLBCL; Gene Expression; Micro-RNA; miR-155; NF-κB; NF-κB Transcription Factor; PU.1; Signal Transduction; NF-κB; Gene Expression; DLBCL; Signal Transduction; B-cell Lymphoma; miR-155; NF-κB Transcription Factor; Micro-RNA; PU.1; CD10

Cell-surface protein CD10 is a prognostic marker for diffuse large B-cell lymphoma (DLBCL), where high expression of CD10 is found in the germinal center B-cell (GCB) subtype and CD10 expression is low or absent in the activated B-cell (ABC) subtype. As compared with the GCB subtype, patients with A...