Solution structure of sperm lysin yields novel insights into molecular dynamics of rapid protein evolution

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 115; no. 6; pp. 1310 - 1315
• Main Authors: Wilburn, Damien B., Tuttle, Lisa M., Klevit, Rachel E., Swanson, Willie J.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 06.02.2018
• Subjects: Binding; Biochemistry; Biological activity; Biological evolution; Biological Sciences; Clustering; Crystal structure; Crystallography; Evolution; Haliotis rufescens; Molecular dynamics; Mollusks; Mutagenesis; NMR; Nuclear magnetic resonance; Physiochemistry; Positive selection; Proteins; Shellfish; Site-directed mutagenesis; Sperm; fertilization; nuclear magnetic resonance; sexual selection

Protein evolution is driven by the sum of different physiochemical and genetic processes that usually results in strong purifying selection to maintain biochemical functions. However, proteins that are part of systems under arms race dynamics often evolve at unparalleled rates that can produce atypi...