Reactive astrocytes associated with prion disease impair the blood brain barrier

• Published in: Neurobiology of disease Vol. 185; p. 106264
• Main Authors: Kushwaha, Rajesh, Li, Yue, Makarava, Natallia, Pandit, Narayan P., Molesworth, Kara, Birukov, Konstantin G., Baskakov, Ilia V.
• Format: Journal Article
• Language: English
• Published: Elsevier 01.09.2023
• Subjects: Blood-brain barrier; Endothelial cells; Neuroinflammation; Prion diseases; Prions; Reactive astrocytes

BACKGROUNDImpairment of the blood-brain barrier (BBB) is considered to be a common feature among neurodegenerative diseases, including Alzheimer's, Parkinson's and prion diseases. In prion disease, increased BBB permeability was reported 40 years ago, yet the mechanisms behind the loss of...