Reactive oxygen species and cancer: A complex interaction

• Published in: Cancer letters Vol. 452; pp. 132 - 143
• Main Authors: Saikolappan, Sankaralingam, Kumar, Binod, Shishodia, Gauri, Koul, Sweaty, Koul, Hari K.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.06.2019; Elsevier Limited
• Subjects: Androgens; Antioxidants; Apoptosis; Breast cancer; Cancer; Cancer therapies; Cell Hypoxia - physiology; Deoxyribonucleic acid; DNA; DNA methylation; Genotype & phenotype; Homeostasis; Humans; Hypoxia; Hypoxia Re-Oxygenation; Metabolism; Metabolites; Metastases; Metastasis; Mitochondria; Mitochondrial DNA; Mutation; NADPH Oxidase 4 - metabolism; Neoplasms - pathology; NF-E2-Related Factor 2 - metabolism; Ovarian cancer; Oxidation-Reduction; Oxidative stress; Prostate cancer; Reactive oxygen species; Reactive Oxygen Species - metabolism; ROS; Signal Transduction; Solid tumors; Transcription factors; Tumor Microenvironment - physiology; Tumorigenesis; Tumors; CDKN1A; ALS; PTEN; RTK; EGFR; PCa; ADT; DHT; CSC; Nrf2; GATOR1; mROS; GC; JAK2; GSH; FoxO; APE1; VEGF; IGF1; MAPK; Hypoxia Re-Oxygenation; EMT; SIRT3; TRX1; AR; STAT; CXCL12; PDAC; TEC; ARE; NOX; ROS; TGFβ; TFAM; ATM; ATP; CRPC; Cancer; ERK

Elevated levels of Reactive Oxygen Species (ROS), increased antioxidant ability and the maintenance of redox homeostasis can cumulatively contribute to tumor progression and metastasis. The sources and the role of ROS in a heterogeneous tumor microenvironment can vary at different stages of tumor: i...