Manganese Redistribution by Calcium-stimulated Vesicle Trafficking Bypasses the Need for P-type ATPase Function

• Published in: The Journal of biological chemistry Vol. 290; no. 15; pp. 9335 - 9347
• Main Authors: García-Rodríguez, Néstor, Manzano-López, Javier, Muñoz-Bravo, Miguel, Fernández-García, Elisabet, Muñiz, Manuel, Wellinger, Ralf Erik
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.04.2015; American Society for Biochemistry and Molecular Biology
• Subjects: ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Calcium - metabolism; Calcium - pharmacology; Calcium-Transporting ATPases - genetics; Calcium-Transporting ATPases - metabolism; Cation Transport Proteins - genetics; Cation Transport Proteins - metabolism; Endoplasmic Reticulum - metabolism; Endosomes - metabolism; Gene Expression Profiling; Genetic Disease; Golgi; Golgi Apparatus - metabolism; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Humans; Manganese; Manganese - metabolism; Metabolism; Microscopy, Fluorescence; Molecular Chaperones; Mutation; Oligonucleotide Array Sequence Analysis; PMR1; Saccharomyces cerevisiae - drug effects; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Transport Vesicles - drug effects; Transport Vesicles - metabolism; Vesicles; Yeast; PMR1; Vesicles; Golgi; Yeast; Genetic Disease; Manganese

Regulation of intracellular ion homeostasis is essential for eukaryotic cell physiology. An example is provided by loss of ATP2C1 function, which leads to skin ulceration, improper keratinocyte adhesion, and cancer formation in Hailey-Hailey patients. The yeast ATP2C1 orthologue PMR1 codes for a Mn2...