The regulatory factor PcRFX1 controls the expression of the three genes of β-lactam biosynthesis in Penicillium chrysogenum

• Published in: Fungal genetics and biology Vol. 49; no. 11; pp. 866 - 881
• Main Authors: Domínguez-Santos, Rebeca, Martín, Juan-Francisco, Kosalková, Katarina, Prieto, Carlos, Ullán, Ricardo V., García-Estrada, Carlos
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2012
• Subjects: Acremonium chrysogenum; Acyltransferases; Acyltransferases - genetics; Acyltransferases - metabolism; Base Sequence; beta -Galactosidase; beta -Lactam antibiotics; beta-Lactams; beta-Lactams - metabolism; biosynthesis; Development; DNA; enzymology; Fungal Proteins; Fungal Proteins - genetics; Fungal Proteins - metabolism; fungi; Gene Expression Regulation, Fungal; gene overexpression; genetics; metabolism; Molecular modelling; Molecular Sequence Data; Morphology; Nucleotide sequence; Oxidoreductases; Oxidoreductases - genetics; Oxidoreductases - metabolism; Penicillin; Penicillin biosynthesis; Penicillin-Binding Proteins; Penicillin-Binding Proteins - genetics; Penicillin-Binding Proteins - metabolism; Penicillium chrysogenum; Penicillium chrysogenum - enzymology; Penicillium chrysogenum - genetics; Penicillium chrysogenum - metabolism; Penicillium marneffei; Peptide Synthases; Peptide Synthases - genetics; Peptide Synthases - metabolism; promoter regions; Promoter Regions, Genetic; Promoters; Regulation; regulatory proteins; Reporter gene; reporter genes; Secondary metabolites; Signal transduction; Sporulation; Transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; Winged-helix transcription factor; Penicillin biosynthesis; ACV; Sporulation; IPN; Morphology; Development; Regulation; Winged-helix transcription factor; IAT

► A novel transcription factor, PcRFX1, has been characterized in Penicillium chrysogenum. ► PcRFX1 controls the expression of the three penicillin biosynthetic genes. ► Morphology and development seemed not to be controlled by this transcription factor. ► A global analysis of processes putatively r...