The influence of insulin on anticipation and consummatory reward to food intake: A functional imaging study on healthy normal weight and overweight subjects employing intranasal insulin delivery

• Published in: Human brain mapping Vol. 43; no. 18; pp. 5432 - 5451
• Main Authors: Wingrove, Jed, O'Daly, Owen, De Lara Rubio, Alfonso, Hill, Simon, Swedroska, Magda, Forbes, Ben, Amiel, Stephanie, Zelaya, Fernando
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 15.12.2022
• Subjects: Administration, Intranasal; Amygdala; anticipation; Anticipation, Psychological - physiology; Appetite; Appetite loss; Body mass index; Body weight; Brain research; Cognitive ability; consummatory; Control systems; Cross-Over Studies; Decision making; Diabetes; Eating; Food; Food intake; functional imaging; Functional magnetic resonance imaging; Glucose; Hedonic response; Humans; Information processing; Insulin; Insulin receptors; Insulin resistance; Intranasal administration; intranasal insulin; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Males; Mesencephalon; Metabolism; Motivation; Neuroimaging; Obesity; Overweight; Overweight - diagnostic imaging; Overweight - drug therapy; Pharmacology; Phenotypes; Placebos; Prefrontal cortex; Reinforcement; Reward; Stimuli; Sucrose; Weight control; United Kingdom > UK; England; consummatory; functional imaging; intranasal insulin; overweight; anticipation

Aberrant responses within homeostatic, hedonic and cognitive systems contribute to poor appetite control in those with an overweight phenotype. The hedonic system incorporates limbic and meso‐limbic regions involved in learning and reward processing, as well as cortical regions involved in motivatio...