Parkinson‐like early autonomic dysfunction induced by vagal application of DOPAL in rats

• Published in: CNS neuroscience & therapeutics Vol. 27; no. 5; pp. 540 - 551
• Main Authors: Sun, Jie, He, Chao, Yan, Qiu‐Xin, Wang, Hong‐Dan, Li, Ke‐Xin, Sun, Xun, Feng, Yan, Zha, Rong‐Rong, Cui, Chang‐Peng, Xiong, Xue, Gao, Shan, Wang, Xue, Yin, Rui‐Xue, Qiao, Guo‐Fen, Li, Bai‐Yan
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2021; John Wiley and Sons Inc
• Subjects: 3,4-Dihydroxyphenylacetic Acid - analogs & derivatives; 3,4-Dihydroxyphenylacetic Acid - pharmacology; alpha-Synuclein - biosynthesis; alpha-Synuclein - genetics; Animals; autonomic dysfunction; Autonomic Nervous System Diseases - etiology; Autonomic Nervous System Diseases - pathology; Baroreceptors; Baroreflex - drug effects; Blood pressure; Blood Pressure - drug effects; Cardiomyocytes; DOPAL; Dopamine; Dysautonomia; Echocardiography; Electrocardiography; Etiology; Gene expression; Hypotension; Hypotension, Orthostatic - physiopathology; Laboratory animals; Male; Mitochondria; Mitochondria, Heart - pathology; Movement disorders; Myocardium - pathology; Myocytes, Cardiac - pathology; Neurodegenerative diseases; Nodose Ganglion - pathology; Original; Parkinson Disease, Secondary - complications; Parkinson Disease, Secondary - pathology; Parkinson's disease; Rats; Rats, Sprague-Dawley; Reflexes; Solitary tract nucleus; Synuclein; Ultrastructure; vagus; Vagus Nerve; α‐synuclein; DOPAL; Parkinson's disease; autonomic dysfunction; vagus; α-synuclein
• ISSN: 1755-5930; 1755-5949; 1755-5949
• DOI: 10.1111/cns.13589

Aim To understand why autonomic failures, a common non‐motor symptom of Parkinson's disease (PD), occur earlier than typical motor disorders. Methods Vagal application of DOPAL (3,4‐dihydroxyphenylacetaldehyde) to simulate PD‐like autonomic dysfunction and understand the connection between PD a...